The following sentence of the Wikipeda Feb 26, 2025 entry for Childrens Health Defense finishes with a bald faced lie. [39] « Kennedy and Nass advocated for the use of ivermectin and hydroxychloroquine instead of vaccination even though those two drugs were already known at the time to be ineffective against COVID. »
Be aware you fact checkers, in order to obtain Emergency Use Authorization for their experimental Covid 19, « vaccines », the drug makers were obliged to say there was no effective treatment. Except, there was, from the outset.
I will relate my own experience with Ivermectin and Hydroxychloroquine.
January 2020 there came from China frightening news of a mysterious respiratory illness. Mid January on French Television Dr Didier Raoult, the respected microbiolgist expert on infectious diseases, announced that this was a Coronavirus which would be easy to treat. He WAS successfully treating it in his Marseille clinic/hospital using hydroxychloroquine (HCQ) . I surmised he should receive the Nobal Prize for resolving what appeared to be very serious disease. (At least one video appeared of people falling dead on the street in China)
Then late January the Minister of Health Dr Agnès Buzyn removed HCQ, an anti-malarial, from the over the counter market where it had been for over 50 years as a mainstay for people traveling to Africa and IndoChina. Apparently at the same time a large stock of HCQ disappeared from the French hospitals.
I already thought ill of Dr Buzyn who the previous summer had attacked
reimbursement for Homeopathy. My husband remarked at the time she with her husband Yves Levy were close to the Big Pharma industry. About this time Jan 2020 she resigned from her position to run for Mayor of Paris, which she lost.
A year later she was rewarded for her pro Pharma efforts by being named the laison officer between the WHO and Bill and Melinda Gates Foundation who had acted together to suppress HCQ in favor of the experimental mRNA injections released December 2020. Already we can see how this fits together.
I suspected foul play when HCQ disappeared from the shelves. April 1, 2020 I posted a letter written by Dr Zev Zelenko to President Trump in which he presented his effective out patient treatment for Covid : HCQ 200mg, Azithromycine 500 mg, 50 mg elemental Zinc. HCQ is an ionophore which aids the absorption of Zinc into the cell. President Trump apparently paid for a large stock of HCQ to be given to the American public. Over the next few months a series of fraudulent studies claimed to discredit HCQ and by mid summer there was no longer any talk of proposing its use for treating Covid 19 in the USA or Europe.This frightened me. (See my substack article « Covid Vaccine : A Sordid Tale » Aug 1, 2020)
May 2020 I had requested prescriptions for Ivermectin, Azithromycine and Doxycycline from my local MD . (Ivermectin wasn’t on the radar yet unlike the already banned HCQ. My recent request for the same thing was denied by the current MD who apparently is following orders to deny Ivermectin.)
Summer 2020 I came upon the site Swiss Policy Research by accident. There I found a resource in India to buy Ivermectin as well as the recommended dose .2 mg/kg which for me meant 11 mg. So I ordered the Ivermectin which came in 6mg and 12mg tabs to have on hand. September 2020 with my American friend, a Scientist disgusted with the fraudulent HCQ studies, we purchased HCQ from a Hong Kong Pharmacy which she brought with her on a visit. I also purchased a Russian HCQ gel from a Czech pharmacy to be inserted into the nose. So I felt prepared
On my blog mscureenigmas.net I published My Covid 19 Solution on September 19, 2020. (see below) So I felt confident I could handle a Covid 19 illness. I was telling my cousins on Zoom we didn’t need a vaccine, there were effective treatments. No, no, no they wouldn’t feel safe until they had the vaccine, they ignored me. Too bad for them . I didn’t realize at the time the injections would be so harmful.
Over the winter my husband fell ill with a cold. When he realized he had lost his sense of smell, a known Covid 19 symptom, we panicked, fearing he had waited too long for the treatment to be effective. In the end it was the HCQ which brought the fever down and put him on the road to recovery. Next it was my turn. The fever turned my legs into spaghetti, I couldn’t walk. Mid afternoon I took a 12mg pill of Ivermectin. 12 hours later the fever broke and I was on the road to recovery. I continued taking the 12mg pill for 5 days. It’s amazing how effective that medication can be. Researchers in Aix en Provence explained why Ivermectin worked so quickly and so well. Family testimony of dying Covid patients in hospital were equally amazed at how well Ivermectin « worked »
Sept 2023 I gave my 94 year old mother who was visiting me in France some 12mg Ivermectin pills to take home with her to the USA. She had fallen ill with a blocked artery after having been « vaccinated » in 2021. Rapid response by my sister probably saved her life. After a disagreeable hospital stay, she agreed not to get the Covid shot again.
This past Autumn 2024, Covid was circulating in her Senior Center. She began taking the Ivermectin on Saturday and was relieved by Monday after a harrowing week-end of symptoms. She knew the Ivermectin worked from a previous experience. Then a month later Covid again, and again she recovered with ease which impressed her fellow Seniors AND her MD who asked where she had obtained the Ivermectin. My mother asked her MD why she couldn’t prescribe it for her directly. Response : « They don’t want to admit they were wrong. »
Apparently American MDs can now prescribe Ivermectin after the FDA was sued for smearing the medication as horse paste. This is not the case in France where the High Medical Council apparently has ordered their MDs not to treat Covid correctly and to prescribe Ivermectin only for parasites.. It concerns me that Ivermectin has become unavailable overseas as well for shipment to France. Is there some thought that it will be effective in treating the next so called viral « pandemic ». Am I paranoid ? Yes.
The following quotes come from an excellent Substack article by Sasha Latypova « Are Covid Vaccines Gene Therapies ? » Sasha Latypova has 25 years experience in pharmaceutical research and development. She has supervised more than sixty clinical trials of new drugs for the industry and understands every step of the regulatory protocols that govern bona fide studies and trials.
« The FDA of course knew mRNA vaxxes are exactly the same technology as gene therapies, and they knew it was going to be deadly, disabling and sterilizing and causing cancer and other adverse events, and also produce indefinite spike expression in some people, because this type of technology has been in development for a long time. The 2015 FDA Guidance for gene therapies lists the examples of risks they already knew by then… he FDA are the competent authority, they document their knowledge in Industry Guidance documents, and therefore, "we didn't know" doesn't fly as defense for them. They knew very well if this is injected into billions of people, millions will be killed and many more millions will suffer permanent disability. They didn’t make any mistakes. Their actions were deliberate and pre-planned…
The FDA misused and abused federal law and their authority…
The FDA uses word games to pretend these risks do not apply to covid vaxxes. The current law allows them to simply declare something a "gene therapy" or "vaccine" or "countermeasure", and then use entirely different statutory/regulatory frameworks for the same technology injected into people on this basis. These are 3 categories of use/application, not different technologies… That's why we have seen in the past 4 years that no matter what adverse event data presented to them, the FDA always says that "covid vaccines are safe and effective". It's not because they don't know that these things are killing millions of people, it's only because the law permits them to disregard this knowledge. And they are evil people using bad law as a cover to injure and kill with impunity, that's of course the main reason."
My Covid 19 Solution September 19, 2020 (BEFORE THE VAX)
I have finally obtained the Hydroxychloroquine by going through a Hong Kong pharmacy. It is ridiculous that a medicine with a 70 year good track record became illegal in France (always available over the counter) thanks to the Health Minister Agnes Buzyn’s Ukaz in January 2020. Since the HK Pharmacy would not ship to France, I asked a friend in the USA to order it for me and my husband and then mail it on to me. It arrived by mail here on Friday. (My friend ordered for herself and family as well.)
Clearly the Pharmacy has made reference to Dr Zelenlo’s protocol since the Plaquenil comes in 10 200 mg pill plaquettes.
Dr Zev Zelenko, New York March 23, 2020
Hydroxychloroquine (HCQ) 200mg twice a day for 5 days
Azithromycin 500mg once a day for 5 days
Zinc sulfate 220mg once a day for 5 days »
The Zinc Sulfate 220 mg equals 50 mg elemental Zinc which I can buy in the nutritional supplement section. My Doctor will have to prescribe either the Azithromycin or Doxycycline which are legal.
Before I begin the above protocol the Covid 19 diagnosis should be confirmed. There is a rapid blood « prick » test (like for Diabetes) in some Paris Pharmacies. The airports are using tests with results in 30 minutes.
One has only 5 (max 7) days from symptom onset to be treated with Hydroxychloroquine so timing is critical. If my Oxymeter shows I am losing oxygen, I will act since that is a Covid 19 symptom even if no breathing difficulties have manifested.
Hydroxychloroquine substitutes :
Ivermectin (anti-parasite)
Interferon-Alpha 2b Spray (Cuba) Dr Judy Mikovits
Bromhexine (over the counter)
HCQ is a zinc ionophore which means it facilitates the entry of anti-viral zinc into the cell.
Quercitin supplement is also a Zinc ionophore.
I need to raise my serum Zinc level as well as Confirm D Vitamin level.
The Swiss were following the French lead in banning HCQ until they decided there were to many deaths and costly treatments. So June 11 they approved HCQ to treat Covid 19. Worldwide statistics demonstrate the effectiveness of early use HCQ.
The Swiss Policy Research site article copied below provides an excellent treatment protocol as well as Research sources.
https://swprs.org/on-the-treatment-of-covid-19/
Quote:
"Swiss Policy Research
On the treatment of Covid-19
Published: July 2, 2020; Updated: September 4, 2020
Languages: DE, EN; Share on: Twitter / Facebook
Immunological and serological studies show that most people develop no symptoms or only mild symptoms when infected with the new coronavirus, while some people may experience a more pronounced or critical course of the disease.
Based on the available scientific evidence and current clinical experience, the SPR Collaboration recommends that physicians and authorities consider the following Covid-19 treatment protocol for the early treatment of people at high risk or high exposure (see references below).
Note: Patients are asked to consult a doctor.
Treatment protocol
Prophylaxis
Addendum: Other prescription drugs with first reported successes in the early
medical treatment of Covid-19 are ivermectin (read more) and favipiravir (read more).
Treatment successes
Zinc/HCQ/AZ: US physicians reported an 84% decrease in hospitalization rates, a 50% decrease in mortality rates among already hospitalized patients (if treated early), and an improvement in the condition of patients within 8 to 12 hours. Italian doctors reported a decrease in deaths of 66%.
US physicians also reported a 45% reduction in mortality of hospitalized patients by adding zinc to HCQ/AZ. Another US study reported a rapid resolution of Covid symptoms, such as shortness of breath, based on early outpatient treatment with high-dose zinc.
Bromhexine: Iranian doctors reported in a study with 78 patients a decrease in intensive care treatments of 82%, a decrease in intubations of 89%, and a decrease in deaths of 100%. Chinese doctors reported a 50% reduction in intubations. Bromhexine is a mucolytic cough medication.
Vitamin D: In a Spanish randomized controlled trial (RCT), high-dose vitamine D (100,000 IU) reduced the risk of requiring intensive care by 96%. A large Israeli study found a strong link between vitamin D deficiency and covid-19 severity.
For more results, see the scientific references below.
Mechanisms of action
Zinc inhibits RNA polymerase activity of coronaviruses and thus blocks virus replication. Hydroxychloroquine and quercetin support the cellular absorption of zinc and have additional anti-viral properties. Bromhexine inhibits the expression of the cellular TMPRSS2 protease and thus the entry of the virus into the cell. Azithromycin prevents bacterial superinfections. Heparin prevents infection-related thromboses and embolisms in patients at risk. (See scientific references below).
See also: Illustration of the mechanisms of action of HCQ, quercetin and bromhexine
Additional notes
The early treatment of patients as soon as the first typical symptoms appear and even without a PCR test is essential to prevent progression of the disease. Zinc, HCQ, quercetin and bromhexin may also be used prophylactically for people at high risk or high exposure (e.g. for health care workers).
In contrast, isolating infected high-risk patients at home and without early treatment until they develop serious respiratory problems, as often happened during lockdowns, may be detrimental.
The alleged or actual negative results with hydroxychloroquine in some studies were based on delayed use (intensive care patients), excessive doses (up to 2400mg per day), manipulated data sets (the Surgisphere scandal), or ignored contraindications (e.g., favism or heart disease).
Early treatment based on the above protocol is intended to avoid hospitalization. If hospitalization nevertheless becomes necessary, experienced ICU doctors recommend avoiding invasive ventilation (intubation) whenever possible and using oxygen therapy (HFNC) instead.
It is conceivable that the above treatment protocol, which is simple, safe and inexpensive, could render more complex medications, vaccinations, and other
measures largely obsolete.
Background
The efficacy of HCQ against SARS coronaviruses was established in 2005 in the wake of the SARS-1 epidemic. The efficacy of zinc in blocking RNA replication of coronaviruses was discovered in 2010 by world-leading SARS virologist Ralph Baric. The efficacy of HCQ in supporting the cellular uptake of zinc was discovered in 2014 as part of cancer research. The efficacy of the flavonoid quercetin in supporting the cellular uptake of zinc was also discovered in 2014. The efficacy of bromhexine in blocking cell entry of coronaviruses was established in 2017.
Stages of covid disease (EVMS)
References
General
Tags : Covid 19, Hydroxychloroquine, Dr Zelenko, Ivermectin, Interferon Alpha 2b spray, Dr Mikovits, Bromhexine, Quercetin, Zinc Ionophore, Heparin, Favipiravir
See also https://docs4opendebate.be/en/open-letter/
The following sentence of the Wikipeda Feb 26, 2025 entry for Childrens Health Defense finishes with a bald faced lie. [39] « Kennedy and Nass advocated for the use of ivermectin and hydroxychloroquine instead of vaccination even though those two drugs were already known at the time to be ineffective against COVID. »
Be aware you fact checkers, in order to obtain Emergency Use Authorization for their experimental Covid 19, « vaccines », the drug makers were obliged to say there was no effective treatment. Except, there was, from the outset.
I will relate my own experience with Ivermectin and Hydroxychloroquine.
January 2020 there came from China frightening news of a mysterious respiratory illness. Mid January on French Television Dr Didier Raoult, the respected microbiolgist expert on infectious diseases, announced that this was a Coronavirus which would be easy to treat. He WAS successfully treating it in his Marseille clinic/hospital using hydroxychloroquine (HCQ) . I surmised he should receive the Nobal Prize for resolving what appeared to be very serious disease. (At least one video appeared of people falling dead on the street in China)
Then late January the Minister of Health Dr Agnès Buzyn removed HCQ, an anti-malarial, from the over the counter market where it had been for over 50 years as a mainstay for people traveling to Africa and IndoChina. Apparently at the same time a large stock of HCQ disappeared from the French hospitals.
I already thought ill of Dr Buzyn who the previous summer had attacked
reimbursement for Homeopathy. My husband remarked at the time she with her husband Yves Levy were close to the Big Pharma industry. About this time Jan 2020 she resigned from her position to run for Mayor of Paris, which she lost.
A year later she was rewarded for her pro Pharma efforts by being named the laison officer between the WHO and Bill and Melinda Gates Foundation who had acted together to suppress HCQ in favor of the experimental mRNA injections released December 2020. Already we can see how this fits together.
I suspected foul play when HCQ disappeared from the shelves. April 1, 2020 I posted a letter written by Dr Zev Zelenko to President Trump in which he presented his effective out patient treatment for Covid : HCQ 200mg, Azithromycine 500 mg, 50 mg elemental Zinc. HCQ is an ionophore which aids the absorption of Zinc into the cell. President Trump apparently paid for a large stock of HCQ to be given to the American public. Over the next few months a series of fraudulent studies claimed to discredit HCQ and by mid summer there was no longer any talk of proposing its use for treating Covid 19 in the USA or Europe.This frightened me. (See my substack article « Covid Vaccine : A Sordid Tale » Aug 1, 2020)
May 2020 I had requested prescriptions for Ivermectin, Azithromycine and Doxycycline from my local MD . (Ivermectin wasn’t on the radar yet unlike the already banned HCQ. My recent request for the same thing was denied by the current MD who apparently is following orders to deny Ivermectin.)
Summer 2020 I came upon the site Swiss Policy Research by accident. There I found a resource in India to buy Ivermectin as well as the recommended dose .2 mg/kg which for me meant 11 mg. So I ordered the Ivermectin which came in 6mg and 12mg tabs to have on hand. September 2020 with my American friend, a Scientist disgusted with the fraudulent HCQ studies, we purchased HCQ from a Hong Kong Pharmacy which she brought with her on a visit. I also purchased a Russian HCQ gel from a Czech pharmacy to be inserted into the nose. So I felt prepared
On my blog mscureenigmas.net I published My Covid 19 Solution on September 19, 2020. (see below) So I felt confident I could handle a Covid 19 illness. I was telling my cousins on Zoom we didn’t need a vaccine, there were effective treatments. No, no, no they wouldn’t feel safe until they had the vaccine, they ignored me. Too bad for them . I didn’t realize at the time the injections would be so harmful.
Over the winter my husband fell ill with a cold. When he realized he had lost his sense of smell, a known Covid 19 symptom, we panicked, fearing he had waited too long for the treatment to be effective. In the end it was the HCQ which brought the fever down and put him on the road to recovery. Next it was my turn. The fever turned my legs into spaghetti, I couldn’t walk. Mid afternoon I took a 12mg pill of Ivermectin. 12 hours later the fever broke and I was on the road to recovery. I continued taking the 12mg pill for 5 days. It’s amazing how effective that medication can be. Researchers in Aix en Provence explained why Ivermectin worked so quickly and so well. Family testimony of dying Covid patients in hospital were equally amazed at how well Ivermectin « worked »
Sept 2023 I gave my 94 year old mother who was visiting me in France some 12mg Ivermectin pills to take home with her to the USA. She had fallen ill with a blocked artery after having been « vaccinated » in 2021. Rapid response by my sister probably saved her life. After a disagreeable hospital stay, she agreed not to get the Covid shot again.
This past Autumn 2024, Covid was circulating in her Senior Center. She began taking the Ivermectin on Saturday and was relieved by Monday after a harrowing week-end of symptoms. She knew the Ivermectin worked from a previous experience. Then a month later Covid again, and again she recovered with ease which impressed her fellow Seniors AND her MD who asked where she had obtained the Ivermectin. My mother asked her MD why she couldn’t prescribe it for her directly. Response : « They don’t want to admit they were wrong. »
Apparently American MDs can now prescribe Ivermectin after the FDA was sued for smearing the medication as horse paste. This is not the case in France where the High Medical Council apparently has ordered their MDs not to treat Covid correctly and to prescribe Ivermectin only for parasites.. It concerns me that Ivermectin has become unavailable overseas as well for shipment to France. Is there some thought that it will be effective in treating the next so called viral « pandemic ». Am I paranoid ? Yes.
The following quotes come from an excellent Substack article by Sasha Latypova « Are Covid Vaccines Gene Therapies ? » Sasha Latypova has 25 years experience in pharmaceutical research and development. She has supervised more than sixty clinical trials of new drugs for the industry and understands every step of the regulatory protocols that govern bona fide studies and trials.
« The FDA of course knew mRNA vaxxes are exactly the same technology as gene therapies, and they knew it was going to be deadly, disabling and sterilizing and causing cancer and other adverse events, and also produce indefinite spike expression in some people, because this type of technology has been in development for a long time. The 2015 FDA Guidance for gene therapies lists the examples of risks they already knew by then… he FDA are the competent authority, they document their knowledge in Industry Guidance documents, and therefore, "we didn't know" doesn't fly as defense for them. They knew very well if this is injected into billions of people, millions will be killed and many more millions will suffer permanent disability. They didn’t make any mistakes. Their actions were deliberate and pre-planned…
The FDA misused and abused federal law and their authority…
The FDA uses word games to pretend these risks do not apply to covid vaxxes. The current law allows them to simply declare something a "gene therapy" or "vaccine" or "countermeasure", and then use entirely different statutory/regulatory frameworks for the same technology injected into people on this basis. These are 3 categories of use/application, not different technologies… That's why we have seen in the past 4 years that no matter what adverse event data presented to them, the FDA always says that "covid vaccines are safe and effective". It's not because they don't know that these things are killing millions of people, it's only because the law permits them to disregard this knowledge. And they are evil people using bad law as a cover to injure and kill with impunity, that's of course the main reason."
My Covid 19 Solution September 19, 2020 (BEFORE THE VAX)
I have finally obtained the Hydroxychloroquine by going through a Hong Kong pharmacy. It is ridiculous that a medicine with a 70 year good track record became illegal in France (always available over the counter) thanks to the Health Minister Agnes Buzyn’s Ukaz in January 2020. Since the HK Pharmacy would not ship to France, I asked a friend in the USA to order it for me and my husband and then mail it on to me. It arrived by mail here on Friday. (My friend ordered for herself and family as well.)
Clearly the Pharmacy has made reference to Dr Zelenlo’s protocol since the Plaquenil comes in 10 200 mg pill plaquettes.
Dr Zev Zelenko, New York March 23, 2020
Hydroxychloroquine (HCQ) 200mg twice a day for 5 days
Azithromycin 500mg once a day for 5 days
Zinc sulfate 220mg once a day for 5 days »
The Zinc Sulfate 220 mg equals 50 mg elemental Zinc which I can buy in the nutritional supplement section. My Doctor will have to prescribe either the Azithromycin or Doxycycline which are legal.
Before I begin the above protocol the Covid 19 diagnosis should be confirmed. There is a rapid blood « prick » test (like for Diabetes) in some Paris Pharmacies. The airports are using tests with results in 30 minutes.
One has only 5 (max 7) days from symptom onset to be treated with Hydroxychloroquine so timing is critical. If my Oxymeter shows I am losing oxygen, I will act since that is a Covid 19 symptom even if no breathing difficulties have manifested.
Hydroxychloroquine substitutes :
Ivermectin (anti-parasite)
Interferon-Alpha 2b Spray (Cuba) Dr Judy Mikovits
Bromhexine (over the counter)
HCQ is a zinc ionophore which means it facilitates the entry of anti-viral zinc into the cell.
Quercitin supplement is also a Zinc ionophore.
I need to raise my serum Zinc level as well as Confirm D Vitamin level.
The Swiss were following the French lead in banning HCQ until they decided there were to many deaths and costly treatments. So June 11 they approved HCQ to treat Covid 19. Worldwide statistics demonstrate the effectiveness of early use HCQ.
The Swiss Policy Research site article copied below provides an excellent treatment protocol as well as Research sources.
https://swprs.org/on-the-treatment-of-covid-19/
Quote:
"Swiss Policy Research
On the treatment of Covid-19
Published: July 2, 2020; Updated: September 4, 2020
Languages: DE, EN; Share on: Twitter / Facebook
Immunological and serological studies show that most people develop no symptoms or only mild symptoms when infected with the new coronavirus, while some people may experience a more pronounced or critical course of the disease.
Based on the available scientific evidence and current clinical experience, the SPR Collaboration recommends that physicians and authorities consider the following Covid-19 treatment protocol for the early treatment of people at high risk or high exposure (see references below).
Note: Patients are asked to consult a doctor.
Treatment protocol
Prophylaxis
- Zinc (50mg to 100mg per day)
- Quercetin (500mg to 1000mg per day)
- Bromhexine (25mg to 50mg per day)
- Vitamins C (1000mg) and D (2000 u/d)
- Zinc (75mg to 150mg per day)
- Quercetin (500mg to 1500mg per day)
- Bromhexine (50mg to 75mg per day)
- Vitamins C (1000mg) and D (4000 u/d)
- Hydroxychloroquine (400mg per day)
- High-dose vitamin D (1x 100,000 IU)
- Azithromycin (up to 500mg per day)
- Heparin (usual dosage)
Addendum: Other prescription drugs with first reported successes in the early
medical treatment of Covid-19 are ivermectin (read more) and favipiravir (read more).
Treatment successes
Zinc/HCQ/AZ: US physicians reported an 84% decrease in hospitalization rates, a 50% decrease in mortality rates among already hospitalized patients (if treated early), and an improvement in the condition of patients within 8 to 12 hours. Italian doctors reported a decrease in deaths of 66%.
US physicians also reported a 45% reduction in mortality of hospitalized patients by adding zinc to HCQ/AZ. Another US study reported a rapid resolution of Covid symptoms, such as shortness of breath, based on early outpatient treatment with high-dose zinc.
Bromhexine: Iranian doctors reported in a study with 78 patients a decrease in intensive care treatments of 82%, a decrease in intubations of 89%, and a decrease in deaths of 100%. Chinese doctors reported a 50% reduction in intubations. Bromhexine is a mucolytic cough medication.
Vitamin D: In a Spanish randomized controlled trial (RCT), high-dose vitamine D (100,000 IU) reduced the risk of requiring intensive care by 96%. A large Israeli study found a strong link between vitamin D deficiency and covid-19 severity.
For more results, see the scientific references below.
Mechanisms of action
Zinc inhibits RNA polymerase activity of coronaviruses and thus blocks virus replication. Hydroxychloroquine and quercetin support the cellular absorption of zinc and have additional anti-viral properties. Bromhexine inhibits the expression of the cellular TMPRSS2 protease and thus the entry of the virus into the cell. Azithromycin prevents bacterial superinfections. Heparin prevents infection-related thromboses and embolisms in patients at risk. (See scientific references below).
See also: Illustration of the mechanisms of action of HCQ, quercetin and bromhexine
Additional notes
The early treatment of patients as soon as the first typical symptoms appear and even without a PCR test is essential to prevent progression of the disease. Zinc, HCQ, quercetin and bromhexin may also be used prophylactically for people at high risk or high exposure (e.g. for health care workers).
In contrast, isolating infected high-risk patients at home and without early treatment until they develop serious respiratory problems, as often happened during lockdowns, may be detrimental.
The alleged or actual negative results with hydroxychloroquine in some studies were based on delayed use (intensive care patients), excessive doses (up to 2400mg per day), manipulated data sets (the Surgisphere scandal), or ignored contraindications (e.g., favism or heart disease).
Early treatment based on the above protocol is intended to avoid hospitalization. If hospitalization nevertheless becomes necessary, experienced ICU doctors recommend avoiding invasive ventilation (intubation) whenever possible and using oxygen therapy (HFNC) instead.
It is conceivable that the above treatment protocol, which is simple, safe and inexpensive, could render more complex medications, vaccinations, and other
measures largely obsolete.
Background
The efficacy of HCQ against SARS coronaviruses was established in 2005 in the wake of the SARS-1 epidemic. The efficacy of zinc in blocking RNA replication of coronaviruses was discovered in 2010 by world-leading SARS virologist Ralph Baric. The efficacy of HCQ in supporting the cellular uptake of zinc was discovered in 2014 as part of cancer research. The efficacy of the flavonoid quercetin in supporting the cellular uptake of zinc was also discovered in 2014. The efficacy of bromhexine in blocking cell entry of coronaviruses was established in 2017.
Stages of covid disease (EVMS)
References
General
- EVMS Critical Care Covid-19 Management Protocol (Paul Marik, MD, June 2020)
- Study: Effect of Zinc Salts on Respiratory Syncytial Virus Replication (Suara & Crowe, AAC, 2004)
- Study: Zinc Inhibits Coronavirus and Arterivirus RNA Polymerase Activity In Vitro and Zinc Ionophores Block the Replication of These Viruses in Cell Culture (Velthuis et al, PLOS Path, 2010)
- Study: Zinc for the common cold (Cochrane Systematic Review, 2013)
- Study: Hydroxychloroquine and azithromycin plus zinc vs hydroxychloroquine and azithromycin alone: outcomes in hospitalized COVID-19 patients (Carlucci et al., MedRxiv, May 2020)
- Study: Treatment of SARS-CoV-2 with high dose oral zinc salts: A report on four patients (Eric Finzi, International Journal of Infectious Diseases, June 2020)
- Review: Does zinc supplementation enhance the clinical efficacy of chloroquine/ hydroxychloroquine to win today’s battle against COVID-19? (Derwand & Scholz, MH, 2020)
- Review: Zinc supplementation to improve treatment outcomes among children diagnosed with respiratory infections (WHO, Technical Report, 2011)
- Article: Can Zinc Lozenges Help with Coronavirus Infections? (McGill University, March 2020)
- Study: Small molecules blocking the entry of severe acute respiratory syndrome coronavirus into host cells (Ling Yi et al., Journal of Virology, 2004)
- Study: Zinc Ionophore Activity of Quercetin and Epigallocatechin-gallate: From Hepa 1-6 Cells to a Liposome Model (Dabbagh et al., JAFC, 2014)
- Study: Quercetin as an Antiviral Agent Inhibits Influenza A Virus Entry (Wu et al, Viruses, 2016)
- Study: Quercetin and Vitamin C: An Experimental, Synergistic Therapy for the Prevention and Treatment of SARS-CoV-2 Related Disease (Biancatelli et al, Front. in Immun., June 2020)
- Report: EVMS Critical Care Covid-19 Management Protocol (Paul Marik, MD, June 2020)
- Study: TMPRSS2: A potential target for treatment of influenza virus and coronavirus infections (Wen Shen et al., Biochimie Journal, 2017)
- Letter: Repurposing the mucolytic cough suppressant and TMPRSS2 protease inhibitor bromhexine for the prevention and management of SARS-CoV-2 infection (Maggio and Corsini, Pharmacological Research, April 2020)
- Study: Potential new treatment strategies for COVID-19: is there a role for bromhexine as add-on therapy? (Depfenhart et al., Internal and Emergency Medicine, May 2020)
- Study: Bromhexine Hydrochloride: Potential Approach to Prevent or Treat Early Stage COVID-19 (Stepanov and Lierz, Journal of Infectious Diseases and Epidemiology, June 2020)
- Study: TMPRSS2 inhibitors, Bromhexine, Aprotinin, Camostat and Nafamostat as potential treatments for COVID-19 (Arsalan Azimi, Drug Target Review, June 2020)
- Trial: Effect of bromhexine on clinical outcomes and mortality in COVID-19 patients: A randomized clinical trial (Ansarin et al., BioImpacts, July 2020): “There was a significant reduction in ICU admissions (2 out of 39 vs. 11 out of 39), intubation (1 out of 39 vs. 9 out of 39) and death (0 vs. 5) in the bromhexine treated group compared to the standard group.”
- Studies: Overview of more than 50 international HCQ studies (C19Study.com)
- Study: Chloroquine is a potent inhibitor of SARS coronavirus infection and spread (Vincent et al., Virology Journal, 2005)
- Study: Chloroquine Is a Zinc Ionophore (Xue et al, PLOS One, 2014)
- Study: Physicians work out treatment guidelines for coronavirus (Korean Biomedical Review, February 2020)
- Study: Expert consensus on chloroquine phosphate for the treatment of novel coronavirus pneumonia (Guangdong Health Commission, February 2020)
- Study: Clinical Efficacy of Chloroquine derivatives in COVID-19 Infection: Comparative meta-analysis between the Big data and the real world (Million et al, NMNI, June 2020)
- Study: Treatment with Hydroxychloroquine, Azithromycin, and Combination in Patients Hospitalized with COVID-19 (Arshad et al, Int. Journal of Infect. Diseases, July 2020)
- Study: COVID-19 Outpatients – Early Risk-Stratified Treatment with Zinc Plus Low Dose Hydroxychloroquine and Azithromycin (Scholz et al., Preprints, July 2020)
- Study: Effectiveness of HCQ in COVID-19 disease (Monforte et al., IJID, July 2020)
- Protocol: Advisory on the use of HCQ as prophylaxis for SARS-CoV-2 infection (Indian Council of Medical Research, March 2020)
- Review: White Paper on Hydroxychloroquine (Dr. Simone Gold, AFD, July 2020)
- Article: The Key to Defeating COVID-19 Already Exists. We Need to Start Using It. (Professor Harvey A. Risch, Newsweek, July 2020)
- Commentary: The versatile heparin in COVID‐19 (Thachil, JTH, April 2020)
- Study: Anticoagulant Treatment Is Associated With Decreased Mortality in Severe Coronavirus Disease 2019 Patients With Coagulopathy (Tang et al, JTH, May 2020)
- Study: Autopsy Findings and Venous Thromboembolism in Patients With COVID-19 (Wichmann et al., Annals of Internal Medicine, May 2020)
- Article: Anticoagulation Guidance Emerging for Severe COVID-19 (Medpage Today)
- Article: Aspirin may prevent blood clots in COVID-19, study shows (Knowridge Science)
- Facts about Covid-19
- On the effectiveness of face masks
- Studies on the lethality of Covid-19"
- End Quote
Tags : Covid 19, Hydroxychloroquine, Dr Zelenko, Ivermectin, Interferon Alpha 2b spray, Dr Mikovits, Bromhexine, Quercetin, Zinc Ionophore, Heparin, Favipiravir
See also https://docs4opendebate.be/en/open-letter/
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