On June 28, 2023 the prestigeous BMJ published a study titled « Association between chronic cerebrospinal venous insufficiency and multiple sclerosis: a systematic review and meta-analysis » which was undertaken by a scientific team associated with theDepartment of Neurosurgery, First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.
« Objectives: Numerous studies have indicated that chronic cerebrospinal venous insufficiency is a potential factor in causing multiple sclerosis in recent years, but this conclusion remains unconfirmed. This meta-analysis examined the correlation between multiple sclerosis and chronic cerebrospinal venous insufficiency.
Methods: We searched Embase and Medline (Ovid) for publications published from 1 January 2006 to 1 May 2022. The meta-analysis was performed following Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines.
Results: Eligible studies (n=20) included 3069 participants from seven countries. Pooled analysis indicated that chronic cerebrospinal venous insufficiency was more frequent in patients with multiple sclerosis than in healthy controls (OR 3.36; 95% CI 1.92 to 5.85; p<0.001) with remarkable heterogeneity among studies (I2=79%). Results were more strongly correlated in subsequent sensitivity analyses, but heterogeneity was also more substantial. We removed studies that initially proposed a chronic cerebrospinal venous insufficiency team as well as studies by authors involved in or advocating endovascular therapies.
Conclusions: Chronic cerebrospinal venous insufficiency is significantly associated with multiple sclerosis and it is more prevalent in patients with multiple sclerosis than in healthy individuals, but considerable heterogeneity of results is still observed. »
Yes, while blood flow matters in the Multiple Sclerosis pathology, the origin of the obstructed blood/CSF flow circulation varies (heterogeneity) as will the treatment options.
So let’s consider another aspect of this conundrum.
Dr Zamboni holds that MS is an endothelial disease. So too Covid 19 disease. Covid 19 begins as a respiratory illness which eventually damages the endothelium of
blood vessels leading to many complications.
Let’s consider MS. The MS expert Neurologist Dr Zivadinov has determined that 4 factors characterize MS patients. One of those factors is a history of Mononucleosis caused by the Epstein Barr Virus (EBV). Not everyone carrying the EBV (95%) develops MS.
Lets look at this article :
« Interventional News
https://interventionalnews.com/brave-d…
Brave Dreams trial finds venous angioplasty “safe, but …Web20 nov. 2017
Although CCSVI is thought to be associated with cerebral venous abnormalities, the aetiology of cerebral venous abnormalities and the possible pathophysiological link to MS and other neurological disorders remain unclear. Several studies have suggested that, in the setting of venous flow abnormalities, this potential association is related to the accumulation of leucocytes in the vasculature. »
Question. Does Mononucleosis in particular promote this accumulation of leucocytes in the vasculature ?
Previously posted on my site mscureenigmas.net
mscureenigmas.net
https://www.mscureenigmas.net
Tags: MS, CCSVI, Dr Zamboni, Brave Dreams trial, Dr Zivadinov Mononucleosis, Leucocytes
« Objectives: Numerous studies have indicated that chronic cerebrospinal venous insufficiency is a potential factor in causing multiple sclerosis in recent years, but this conclusion remains unconfirmed. This meta-analysis examined the correlation between multiple sclerosis and chronic cerebrospinal venous insufficiency.
Methods: We searched Embase and Medline (Ovid) for publications published from 1 January 2006 to 1 May 2022. The meta-analysis was performed following Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines.
Results: Eligible studies (n=20) included 3069 participants from seven countries. Pooled analysis indicated that chronic cerebrospinal venous insufficiency was more frequent in patients with multiple sclerosis than in healthy controls (OR 3.36; 95% CI 1.92 to 5.85; p<0.001) with remarkable heterogeneity among studies (I2=79%). Results were more strongly correlated in subsequent sensitivity analyses, but heterogeneity was also more substantial. We removed studies that initially proposed a chronic cerebrospinal venous insufficiency team as well as studies by authors involved in or advocating endovascular therapies.
Conclusions: Chronic cerebrospinal venous insufficiency is significantly associated with multiple sclerosis and it is more prevalent in patients with multiple sclerosis than in healthy individuals, but considerable heterogeneity of results is still observed. »
Yes, while blood flow matters in the Multiple Sclerosis pathology, the origin of the obstructed blood/CSF flow circulation varies (heterogeneity) as will the treatment options.
So let’s consider another aspect of this conundrum.
Dr Zamboni holds that MS is an endothelial disease. So too Covid 19 disease. Covid 19 begins as a respiratory illness which eventually damages the endothelium of
blood vessels leading to many complications.
Let’s consider MS. The MS expert Neurologist Dr Zivadinov has determined that 4 factors characterize MS patients. One of those factors is a history of Mononucleosis caused by the Epstein Barr Virus (EBV). Not everyone carrying the EBV (95%) develops MS.
Lets look at this article :
« Interventional News
https://interventionalnews.com/brave-d…
Brave Dreams trial finds venous angioplasty “safe, but …Web20 nov. 2017
Although CCSVI is thought to be associated with cerebral venous abnormalities, the aetiology of cerebral venous abnormalities and the possible pathophysiological link to MS and other neurological disorders remain unclear. Several studies have suggested that, in the setting of venous flow abnormalities, this potential association is related to the accumulation of leucocytes in the vasculature. »
Question. Does Mononucleosis in particular promote this accumulation of leucocytes in the vasculature ?
Previously posted on my site mscureenigmas.net
mscureenigmas.net
https://www.mscureenigmas.net
Tags: MS, CCSVI, Dr Zamboni, Brave Dreams trial, Dr Zivadinov Mononucleosis, Leucocytes
RSS Feed