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https://www.youtube.com/watch?v=i0m_isndqc0
Disturbing scene from the documentary about MS, "Living Proof
Why is this video « disturbing » ?
Because the renowned MS researcher Dr George Ebers utters the unspeakable truth that he himself would not take the Disease Modifying Drugs (DMDs) They don’t address longterm outcome meaning possible descent into disability, AND they cause serious negative side effects. Matt Embry in his MS Documentary LIVING PROOF agrees with Dr Ebers, listing known side effects from various drugs while providing his own lifestyle change treatment protocols which have controlled his MS.(See 5‘-8' on 10 :36’ clip ).
Thisisms Forum posted a research study which actually confirms the toxicity of some of these drugs.https://www.thisisms.com
Adverse Events Associated With Disease-Modifying Drugs for Multiple Sclerosis: A Multiregional Population-Based Study
Neurology. 2024 Feb 13;102(3):e208006.
Dr Ebers began his research on the natural evolution of MS in 1972. He was right there in the beginning of DMD research in 1987. At a Neurology conference at Barcelone in 2010 he expressed his opinion that the clinical MS drug trials were basically worthless. See
Post by Direct-MS » Mon Nov 01, 2010 3:07 pm on https://www.thisisms.com
Quote
"George Ebers is perhaps the #1 MS researcher in the world and is a professor at Oxford in (Ontario, Canada). Notably he is also one of the few MS researchers who is not compromised by major financial ties to the MS drug companies. He recently expressed his well supported views on, why the clinical trials of the MS drugs are basically worthless, in an abstract for his presentation at a neurology conference in Barcelona. He writes
"Clinical trials of multiple sclerosis have been uniform in utilising invalidated outcome measures. This has occurred to a degree to which it is difficult to find parallels in medicine in general.We have recently evaluated the outcomes which have been used for evaluating past trials leading to drug approval and current trials. It is not a pretty sight.
It is quite clear from natural history studies that relapses have very little if anything to do with long term outcome. Similarly, MRI measures have been thoroughly evaluated within large datasets and found to be similarly non-predictive for meaningful outcomes. The measures of disability used in trials certainly don’t measure unremitting disability as investigators and their industry supporters have claimed.
The widespread embracing of dubious and poorly validated outcomes by some MS investigators, often in contexts where there are egregious conflicts of interest, threaten academic credibility not to mention long term professional autonomy."
Post by Direct-MS » Tue Nov 02, 2010 11:53 am
It is available on the website of the "Controversies in Neurology" Conference in Barcelona. http://comtecmed.com/c ony/2010/scientific_prog.aspx
While you are there check out the Zamboni (for CCSVI) and Stuve (against CCSVI) abstracts as well as some other useful ones
For some reason this lecture did not damage Dr Ebers stellar reputation in the MS research community.
However, when on October 17, 2013 he gave a lecture titled “Critical Review of outcomes used in MS clinical trials” which was posted on You Tube November 4, 2013 by to the European Medicines Agency. www.youtube.com/watch?v=OqY-_K1fYJY, all hell broke loose. Our hero became persona non grata. He lost his association with the prestigious MS research center the Sylvia Lawry center in Munich. Never mind that seven months earlier he had been chosen to receive the National MS Society/American Academy of Neurology’s 2013 John Dystel Prize for Multiple Sclerosis. (Perhaps this ‘was condidered a betrayal’by the MS Society ?)
The following quotes outlining Dr Ebers career come from www.nationalmssociety.org site.
"His studies of twins have shown that susceptibility is partly genetic and partly environmental, indicating that MS is a complex genetic disease. These findings contribute to efforts to end MS through prevention. (Proceedings of the National Academy of Sciences U S A 2003;100:12877) This showed linkage to the Human leukocyte antigen (HLA) complex (genes related to the immune system) on chromosome 6. (Lancet 1982;2:88)…
Research is increasingly pointing to reduced levels of vitamin D in the blood as one factor that can increase the risk of developing MS. (Annals of Neurology 2011;70:881)
Delineating the natural history of MS: Dr. Ebers has performed detailed studies tracking over time the “natural history” of MS in London, Ontario, Canada, following more than 1,000 individuals since 1972. Natural history studies provide important knowledge, such as the average number of MS relapses a person may be expected to experience. This helps to appropriately design clinical trials and interpret their results. These studies have been published in a series of important papers on topics such as the predictive value of the early course of MS (Brain 1989;112:1419), and the features of primary progressive MS. (Brain 1999;122:625)…
Epidemiology of MS: Dr. Ebers’ studies have forged new paths our understanding of who gets MS, which is the goal of epidemiology. In a study of over 40,000 people from Canada, Sweden, Norway and the United Kingdom, Dr. Ebers showed that the relative risk of developing MS is higher if you are born in May (like me) and lower if you are born in November. The finding of a birth pattern suggests the possibility that the origins of the disease date to very early in life. (British Medical Journal 2005;330:120)" (My comment. The Sun related Vitamin D deficiency persists throughout growth. For example, people who moved to Sweden from Iran at an average age of 17 developed MS at the higher Scandinavian rate. (Ahlgren et al., 2010).
Dr. Ebers also has contributed to the study of gender differences in MS. Among other contributions, he documented in 2006 a significant increase in the number of women diagnosed with MS more than men, noting that the female to male ratio in the incidence of MS had increased progressively over the previous 50 years. (Lancet Neurology 2006;5:932) (My comment.. The FDA approved Birth Control Pills in 1960. I suspect use of hormonal therapy has triggered the striking increase in female susceptibility to MS, the original male/female ratio being 1:1.)
A series of studies on the relatives of people with MS including spouses, half-siblings, adoptees, and step-siblings suggested the idea that increases in the risk for developing MS come less from the familial environment than from factors operating at a general population level, such as climate and/or diet. These studies led to examination of role of Vitamin D in MS risk and the potential of vitamin D supplementation for MS patients and their families. (Lancet Neurology 2008;7:268)" End Quote
Apparently in 2013 Dr Ebers did not endorse the CCSVI theory of MS ; As can be seen in the above Documentary LIVING PROOF, by 2017 Dr. Ebers was collaborating with Matt Embry who does recognize the importance of enhanced blood flow through the MS brain.
CONCLUSION : The purpose of my book is to help MSers pursue a healthy lifestyle which will prevent or at least slow descent into disability. In keeping with Dr Ebers indirect advice to avoid DMD toxicity, I will continue to perfect MY SEVEN STEPS TO MULTIPLE SCLEROSIS HEALTH.
Matt Embry’s https://mshope.com is an outstanding complement.
PS. I don't know the details of Dr Ebers' relation with the Sylvia Lawry Centre for Multiple Sclerosis in Munich. What I can see is, without mentioning his name, they have largely adopted his opinion of DMD research.
Quote from their site:
Tags : Dr Georrge Ebers, Matt Embry, DMDs, Disease Modifying Drugs, Living Proof.Docurnentary
https://www.youtube.com/watch?v=i0m_isndqc0
Disturbing scene from the documentary about MS, "Living Proof
Why is this video « disturbing » ?
Because the renowned MS researcher Dr George Ebers utters the unspeakable truth that he himself would not take the Disease Modifying Drugs (DMDs) They don’t address longterm outcome meaning possible descent into disability, AND they cause serious negative side effects. Matt Embry in his MS Documentary LIVING PROOF agrees with Dr Ebers, listing known side effects from various drugs while providing his own lifestyle change treatment protocols which have controlled his MS.(See 5‘-8' on 10 :36’ clip ).
Thisisms Forum posted a research study which actually confirms the toxicity of some of these drugs.https://www.thisisms.com
Adverse Events Associated With Disease-Modifying Drugs for Multiple Sclerosis: A Multiregional Population-Based Study
Neurology. 2024 Feb 13;102(3):e208006.
Dr Ebers began his research on the natural evolution of MS in 1972. He was right there in the beginning of DMD research in 1987. At a Neurology conference at Barcelone in 2010 he expressed his opinion that the clinical MS drug trials were basically worthless. See
Post by Direct-MS » Mon Nov 01, 2010 3:07 pm on https://www.thisisms.com
Quote
"George Ebers is perhaps the #1 MS researcher in the world and is a professor at Oxford in (Ontario, Canada). Notably he is also one of the few MS researchers who is not compromised by major financial ties to the MS drug companies. He recently expressed his well supported views on, why the clinical trials of the MS drugs are basically worthless, in an abstract for his presentation at a neurology conference in Barcelona. He writes
"Clinical trials of multiple sclerosis have been uniform in utilising invalidated outcome measures. This has occurred to a degree to which it is difficult to find parallels in medicine in general.We have recently evaluated the outcomes which have been used for evaluating past trials leading to drug approval and current trials. It is not a pretty sight.
It is quite clear from natural history studies that relapses have very little if anything to do with long term outcome. Similarly, MRI measures have been thoroughly evaluated within large datasets and found to be similarly non-predictive for meaningful outcomes. The measures of disability used in trials certainly don’t measure unremitting disability as investigators and their industry supporters have claimed.
The widespread embracing of dubious and poorly validated outcomes by some MS investigators, often in contexts where there are egregious conflicts of interest, threaten academic credibility not to mention long term professional autonomy."
Post by Direct-MS » Tue Nov 02, 2010 11:53 am
It is available on the website of the "Controversies in Neurology" Conference in Barcelona. http://comtecmed.com/c ony/2010/scientific_prog.aspx
While you are there check out the Zamboni (for CCSVI) and Stuve (against CCSVI) abstracts as well as some other useful ones
For some reason this lecture did not damage Dr Ebers stellar reputation in the MS research community.
However, when on October 17, 2013 he gave a lecture titled “Critical Review of outcomes used in MS clinical trials” which was posted on You Tube November 4, 2013 by to the European Medicines Agency. www.youtube.com/watch?v=OqY-_K1fYJY, all hell broke loose. Our hero became persona non grata. He lost his association with the prestigious MS research center the Sylvia Lawry center in Munich. Never mind that seven months earlier he had been chosen to receive the National MS Society/American Academy of Neurology’s 2013 John Dystel Prize for Multiple Sclerosis. (Perhaps this ‘was condidered a betrayal’by the MS Society ?)
The following quotes outlining Dr Ebers career come from www.nationalmssociety.org site.
"His studies of twins have shown that susceptibility is partly genetic and partly environmental, indicating that MS is a complex genetic disease. These findings contribute to efforts to end MS through prevention. (Proceedings of the National Academy of Sciences U S A 2003;100:12877) This showed linkage to the Human leukocyte antigen (HLA) complex (genes related to the immune system) on chromosome 6. (Lancet 1982;2:88)…
Research is increasingly pointing to reduced levels of vitamin D in the blood as one factor that can increase the risk of developing MS. (Annals of Neurology 2011;70:881)
Delineating the natural history of MS: Dr. Ebers has performed detailed studies tracking over time the “natural history” of MS in London, Ontario, Canada, following more than 1,000 individuals since 1972. Natural history studies provide important knowledge, such as the average number of MS relapses a person may be expected to experience. This helps to appropriately design clinical trials and interpret their results. These studies have been published in a series of important papers on topics such as the predictive value of the early course of MS (Brain 1989;112:1419), and the features of primary progressive MS. (Brain 1999;122:625)…
Epidemiology of MS: Dr. Ebers’ studies have forged new paths our understanding of who gets MS, which is the goal of epidemiology. In a study of over 40,000 people from Canada, Sweden, Norway and the United Kingdom, Dr. Ebers showed that the relative risk of developing MS is higher if you are born in May (like me) and lower if you are born in November. The finding of a birth pattern suggests the possibility that the origins of the disease date to very early in life. (British Medical Journal 2005;330:120)" (My comment. The Sun related Vitamin D deficiency persists throughout growth. For example, people who moved to Sweden from Iran at an average age of 17 developed MS at the higher Scandinavian rate. (Ahlgren et al., 2010).
Dr. Ebers also has contributed to the study of gender differences in MS. Among other contributions, he documented in 2006 a significant increase in the number of women diagnosed with MS more than men, noting that the female to male ratio in the incidence of MS had increased progressively over the previous 50 years. (Lancet Neurology 2006;5:932) (My comment.. The FDA approved Birth Control Pills in 1960. I suspect use of hormonal therapy has triggered the striking increase in female susceptibility to MS, the original male/female ratio being 1:1.)
A series of studies on the relatives of people with MS including spouses, half-siblings, adoptees, and step-siblings suggested the idea that increases in the risk for developing MS come less from the familial environment than from factors operating at a general population level, such as climate and/or diet. These studies led to examination of role of Vitamin D in MS risk and the potential of vitamin D supplementation for MS patients and their families. (Lancet Neurology 2008;7:268)" End Quote
Apparently in 2013 Dr Ebers did not endorse the CCSVI theory of MS ; As can be seen in the above Documentary LIVING PROOF, by 2017 Dr. Ebers was collaborating with Matt Embry who does recognize the importance of enhanced blood flow through the MS brain.
CONCLUSION : The purpose of my book is to help MSers pursue a healthy lifestyle which will prevent or at least slow descent into disability. In keeping with Dr Ebers indirect advice to avoid DMD toxicity, I will continue to perfect MY SEVEN STEPS TO MULTIPLE SCLEROSIS HEALTH.
Matt Embry’s https://mshope.com is an outstanding complement.
PS. I don't know the details of Dr Ebers' relation with the Sylvia Lawry Centre for Multiple Sclerosis in Munich. What I can see is, without mentioning his name, they have largely adopted his opinion of DMD research.
Quote from their site:
- https://www.msard-journal.com/article/S2211-0348(22… · Fichier PDF
Sustained increase of EDSS appeared to be an invalid outcome for 2–3 year clinical trials at least in patients with relapsing-remitting MS. The number of gadolinium-enhancing lesions and T2-lesion load on MRI were shown not to have a meaningful additional predictive value for the disease course. These issues risen some 15 years ago had triggered controversial discussions which have also been noticed by regulatory authorities and they all have not been resolved.
Tags : Dr Georrge Ebers, Matt Embry, DMDs, Disease Modifying Drugs, Living Proof.Docurnentary
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