McGuckin, James Frederick, Jr., M.D., Lic. No. N1760, Philadelphia, PA
On June 10, 2016, the Board and James Frederick McGuckin, Jr., M.D., entered into an Agreed Order requiring Dr. McGuckin to comply with all terms as required by the Agreed Order issued by the Washington Medical Quality Assurance Commission. Dr. McGuckin shall not perform angioplasty and stenting procedures of the venous system for chronic cerebrospinal venous insufficiency (CCSVI) procedures or multiple sclerosis patients in the state of Texas. The Board found Dr. McGuckin entered into an Agreed Order with the Washington Medical Quality Assurance Commission which was based on the determination that Dr. McGuckin performed CCSVI procedures on patients without ensuring Bio-Med IRB obtained an approved Investigation Device Exemption (IDE) from the Food and Drug Administration.
Cece of Thisisms.com posted the above on June 16, 2016.
Dr. McGuckin is a Canadian Interventional Radiologist who wrote the following
§ I have personally studied hundreds of patients with MS. They all have had CCSVI. § The majority of these patients are citizens of Canada, and most of them are enrolled in the Hubbard Registry. § None of these MS patients were normal on venography and all had truncal venous abnormalities. These deformities include malformed valves, significant narrowing, and membranous tissue or webbing inside the vein. Over 80% of patients have had a positive response to the treatment with a reduction in their symptoms. § The focus of MS research should include discovering the etiology of MS, improving treatments for MS patients, evaluating the safety and efficacy of treating the vascular abnormalities associated with CCSVI/MS, and developing therapies that augment and preserve the improvements developed through endovascular treatment.
Date unknown. The FDA closed down the Hubbard Registry in 2012. I believe that in itself was a semi-criminal act. Why did they do it? The Registry would have given CCSVI patients and practitioners a true idea of Venoplasty outcomes.
I believe one should avoid the MS diagnosis. It is of little use and will do great harm if one wants a Medical Insurance Company to pay for the CCSVI Venoplasty procedure.
I think one should ask to be diagnosed with a Neurological disorder of unknown origin. Forget the MS (Anyway, that wouldn’t be a false statement, for the Neurology profession, the origins of the MS ARE unknown.)
The following quote comes from the May 23, 2014 blog post “Vitamin D, Veins, and the Epstein Barr Virus” from my site MS Cure Enigmas.net www.mscureenigmas.net/
On March 21, 2013 it was announced that Professor George C. Ebers, MD, of University of Oxford in London, had been chosen to receive the National MS Society/American Academy of Neurology’s 2013 John Dystel Prize for Multiple Sclerosis… The Neurology Community was less pleased with Dr. Ebers when on 17 October 2013 he gave a lecture titled “Critical Review of outcomes used in MS clinical trials” which was posted on You Tube November 4, 2013 by the European Medicines Agency… www.youtube.com/watch?v=OqY-_K1fYJY
Dr. Ebers basically said that current MS medications do NOT prevent descent into Progressive MS disability. See my blog (MS Drug/MRI Fallacy January 5, 2014) DMD’s treat the inflammation of the early RRMS. Once the Progressive stage sets in, they don’t work and decline sets in. Apparently the brain atrophies as do the veins draining the brain. It has been demonstrated that blood transit time in MS patients is one half that of normals. The question is one of perfusion i.e. blood flow, volume and mean transit time. ALL brain fluids contribute to adequate blood flow.
Dr. Ebers has engaged in debates denouncing (politely) the failure of Neurologists to face facts about DMD efficacy, arguing that the CCSVI controversy had revealed to what extent MS patients don’t trust their Doctors. If one obediently follows standard therapy only to finish in a wheelchair, by which time the CCSVI option and/or the “nourish the grey matter” option are less viable, one will have made a mistake. I believe current research delays owing to ideology and vested interests border on criminal.”
CCSVI MS: A FUNCTIONAL DISORDER UPDATED
It has been over seven years since the Professor Zamboni posted his CCSVI theory on the internet (December 2008) suggesting that MS is in fact a blood circulation disorder of the brain. Since then scientific research has revealed that disruption of ANY fluid bathing the central nervous system (blood, cerebrospinal, lymphatic, glymphatic) can cause “MS” symptoms. This site is intended to share the “liberation” I feel as an MSer who no longer needs to fear inevitable doom.
I first learned about “Liberation Therapy” on the site Daily Kos summer 2010. Professor Zamboni initially proposed using the Sonogram to diagnose veins running from the brain towards the heart – the Internal Jugular Veins and the Vertebral Veins. Once the narrowings/blockages in these veins were observed he recommended opening the stenoses with balloon venoplasty and, if so indicated by the venogram, the chest azygos vein as well. In his paper “CCSVI – A New paradigm and therapy for multiple sclerosis” posted on July 25, 2010, the Interventional Radiologist Salvatore J.A. Sclafani, MD refers to Dr. Zamboni’s work by writing “Chronic cerebrospinal venous insufficiency (CCSVI) is a hemodynamic condition in which cerebrospinal drainage is altered and inhibited. Outflow obstructions of the internal jugular veins (IJVs), vertebral veins, and/or azygos vein ( AZV) and their tributaries result in stasis or reflux of these outflow veins and redirection of flow through vicarious circuits…
On reading this I immediately asked my husband to massage my neck/back, both of us standing. He was to work from the head down to the waist while we both visualized the blood flowing down from my head to circulate through the heart. I felt better at once as the head congestion lifted. Late that summer stress triggered a MS “attack”. I wondered with a heavy heart how much ground I would lose. That evening I performed a TENS acupressure treatment on myself (see Acupuncture blog). I was shocked the next morning to realize the attack had abruptly stopped. Not diminished, not attenuated, but stopped. Years later when I studied my journals and records I realized a Shiatsu massage had abruptly stopped my first major attack in 1980 just when my Neurologist prepared steroid treatment. Opening the flow of blood/fluids was the best treatment.
I launched my site MS Cure Enigmas.net March 2012 by writing:
“In Multiple Sclerosis blood vessels "deformed" by childhood stress cannot accommodate the blood flow. I believe the immune system is activated by blood refluxes which injure the brain and spinal cord. The origin of the refluxes may be structural 1) CCSVI stenosis (as proposed by Professor Zamboni) and/or cerebrospinal fluid pressure or 2) it may be a stress reaction to toxicity.
Epidemiological studies on MS show that those who grow up close to the equator have less chance to develop MS than those living in latitudes closer to the poles. It is the latitude where one lives before age 15 that counts, not where one lives subsequently. It is therefore thought that the lack of sunlight leading to a Vit D deficiency is a factor in susceptibility to MS.
But perhaps an equally important explanation of the geographical factor is Winter Cold.
The shoulders and neck typically tense up under stress thus restricting circulation to and from the brain. Cold weather stiffens the muscles. Winters bring the body aches of colds and flus. Illness itself (e.g. Clamydia Pneumoniae, Mononucleosis) may damage the cell walls and valves of the vascular system.
It is also said that MS patients tend to be high powered, ambitious people. Tensed up in other words. MS cases cluster in northern Europe and North America. Let’s say growing up in a culturally demanding family environment (or in any case stressful) while subject to Cold weather and frequent colds and flus actually compresses and deforms the circulatory system in the child’s developing body. By the time he/she reaches age 15, the damaged blood vessels can no longer accommodate the blood flow. MS first appears in adolescents, seldom in children. Let’s compare the deformity to ancient Chinese footbinding where the tiny child’s foot cannot support the adult woman.
Food intolerances, especially to wheat and dairy products, can further compound the stress. The Neolithic agricultural revolution dates back not much more than 10,000 years, a blink of the eye in terms of biological evolution. Bowel problems are a sure sign of food “stress”. The significant increase in MS cases in Japan over the past 30 years points to food toxicity as root cause.
And the disadvantage of being female. While originally there was no difference in MS incidence between the sexes, over the past 50 years women’s share has increased to the point where up to three out of four MSers are female. What changed 50 years ago? The advent of birth control pills (1960) and hormonal therapies which are known to impact the vascular system adversely.
Maybe the real story behind MS is the damage to the blood vessels caused by growing up in a 1) driven, ambitious or otherwise stressful family environment compounded by 2) a climate of Cold winters which contribute to 3) frequent viral illnesses compounded by 4) an intolerance to the wheat and lactose of a Neolithic diet.”
That analysis is a good beginning, but my thinking has evolved since then. It is believed that the BigPharma/Neurology lobby pressured the FDA to put a stop to CCSVI treatment for MS outside of research trials in May 2012 thus retarding development of appropriate stents and improvements of the procedure, not to mention depriving MS patients of a well documented cure. Avoiding the damning diagnosis MS, Dr. Sclafani has performed over 500 venoplasties for CCSVI and has found the condition in many more vein types than initially proposed by Dr. Zamboni. He recommends use of the Intravenous Ultrasound (IVUS) to allow the Doctor to best judge the size of the balloon – too small the vein re-stenoses, too large the vein wall may be damaged resulting in thrombosis. For him the gold standard for CCSVI diagnosis is the IVUS venoplasty itself, the sonogram being inconclusive. Thus he has been able to overcome difficulties which tended to discredit early treatments.
Another issue overlooked at the outset was the skeletal factor, that pressure ON the vein by a bone, muscle or artery may be obstructing blood flow rather than a problem IN the vein. Chiropractor Dr. Michael Flanagan, author of The Downside of Upright Posture – The Anatomical Causes of Alzheimer’s, Parkinson’s and Multiple Sclerosis estimated that up to 25% of MS cases fall into this category. In this case venoplasty is ill advised since the treatment will not overcome the obstruction and may well damage a healthy vein.
February 13, 2015 PLOS ONE* published a double blind study revealing that it takes twice as long for blood to flow from the heart through the brain and back to the heart in MSers than in normals, this regardless of the MSers condition. In other words, poor blood perfusion through the brain is a marker for MS, it defines MS.
Consider first that neck/back massages can get sluggish blood flowing in my case. Matt Embry uses vigorous exercise. Why should the blood vessels in MSers be so weak that mere muscle tension can disrupt blood circulation? Recent research by Professor Zamboni has found that the endothelium – inner vein wall - cells are absent in the Internal Jugular veins of MS subjects. Without walls the veins could collapse like a flimsy garden hose. Why are these cells missing? Childhood illness, poor nutrition owing to food sensitivities, insufficient Vitamin D ( a form of vein rickets perhaps? A genetic factor specific to MS reinforces the need for Vitamin D.) Whatever the reason, a damaged endothelium is a vital factor. So the slightest tension may impede blood circulation. Foods can act as toxins which cause body tension, glutens being a classic example. Antibiotics as well. The flu can cause the entire body to seize up in cramps which seem to shut down my entire body’s fluid circulation leading to terrible MS symptoms. Anything which causes the body to tense up may trigger MS attacks. I don’t think one need look any further than that.
And Latitude? It's the Sun which brings health through Vitamin D AND the release of Nitric Oxide. Nitric Oxide is a vasodilator critical to the development and function of the vascular system (read endothelium again). (Research into Cardiovascular disease – not MS or CCSVI – led to these insights.) A properly functioning vein wall so critical to blood circulation depends on a healthy life style (diet, supplements, exercise, stress reduction, UV rays). These factors missing during the critical growth period could well lead to a deformed, poorly developed vascular system. The evidence pointing to MS as a circulatory system disease is overwhelming. And the epidemiological factors fall into place.
However, blood is not the only fluid impacting the central nervous system. Obstruction of cerebro-spinal fluid (CSF) which bathes the spine and brain can lead to MS pathology as well. The International Society for Neurovascular Diseases (ISNVD founded in 2011 has done pioneering research into the “interaction between the CSF system and the cerebral venous drainage system”.
I’ve come to think that the 10% PPMS cases exhibit primarily obstructed cerebrospinal fluid (CSF) or direct pressure on the spinal cord itself owing to a damaged, degenerated spine. And the more common RRMS (RelapseRemissionMS) is transformed into the Progressive form as the disease process damages the spine and body structure in general.. (See January 21, 2015 Blog “How RRMS progresses to SPMS”). A complicated interplay of CSF circulation and venous blood circulation suggests that venoplasty may be of limited effectiveness in some patients.
The MS-UK site’s succinct definition of PPMS.
Primary Progressive MS (PPMS) concerns about 10 to 15% of MS cases. In contrast to RRMS (RelapseRemission) cases, the PPMS disease progresses continually without respite after striking an older population (age 40’s to 50’s). Unlike RRMS, there is little to no inflammation, there are fewer brain lesions, the lesions which do exist present fewer inflammatory cells, and more are found on the spinal cord than in the brain which leads to mobility problems. While PPMS cases exhibit less inflammation, there appears to be greater damage to the axons.”
PPMS patients are not included in MS drug research and treatment because both target the myelin damaging inflammation of RelapseRemission MS observed on the MRI, that is to say, the blood reflux (CCSVI).
A point also missing from my original paper is the observed atrophy of brain grey matter as the disease progresses. Blood refluxes damage the myelin white matter which are revealed as MRI lesions during early stage relapses. Eventually the relapses recede as the grey matter deteriorates. (Recent research reveals that MS disability is related to microbleeds in the brain – another manifestation of the critical importance of a healthy endothelium to prevent breach of the blood brain barrier.)
And finally we arrive at an understanding that increased disability is less caused by white matter lesions than grey matter atrophy, a shrinking brain. This puts in doubt the entire immune suppression drug protocol for MS.
So consider the factors. Is blood flow from the brain obstructed by a venous abnormality? How serious is the obstruction? Will simple body tension collapse the vein and impede blood flow, tension caused by emotional stress, the flu, toxins, poor food? Is there a mechanical obstruction pressing on the otherwise healthy vein? Does cerebrospinal fluid flow obstruction damage the axons, the spinal cord? Where is the principle obstruction, how should it be treated? When one considers all the variables, one can understand why venoplasty cannot provide the one and only answer. However, for some it has led to a “miracle” cure.
At this time, Chiropractors familiar with spinal structural conditions are probably best equipped to study, diagnose and even treat skeletal obstructions of blood and cerebrospinal fluid flow through the central nervous system. Dr Michael Flanagan “upright doc” on the Thisisms.com website (CCVBP), (tragically for MSers now deceased,) recommended use of the COX Technic Flexion-Distraction tables (the most advanced is now version 8) to treat spinal conditions. NUCCA (National Upper Cervical Chiropractic Association) Chiropractors specialize in treating the Cervicals and the Atlas Orthogonal (C1). Italian teams of vascular specialists are now studying the phenomonena.
The ideal equipment is the FONAR upright Cine MRI invented by Dr. Damadian – inventor of the original MRI idea - because obstructions in cerebrospinal fluid flow are less likely to be observed by MRIs when the patient is recumbent. For diagnosis of CSF flow there are apparently 15 FONAR sites in the US and one in London. (http://www.fonar.com/news/052114.htm
Osteopaths work to get the body fluids circulating. My Osteopath thinks MSers need the combined skills of a Chiropractor – to free any obstructions by manipulating the skeleton – and an Osteopath to get the fluids circulating. This would include the newly discovered Glymphatic fluid which cleanses the brain during sleep, not to mention the brain’s lymphatic fluid discovered summer 2015.
In conclusion, every effort must be made to stop the blood reflux, stop the relapses, strengthen the veins’endothelium and nourish the grey matter as well as the myelin sheath, the earlier the better. Optimal nutrition, supplements, blood circulation therapies and venoplasty itself if the stenosis is serious all serve this end.
Finally, the Epstein-Barr virus remains dormant throughout the life of MSers after an initial Mononucleosis infection. Did the initial infection damage the endothelium? Does periodic activation of the virus trigger “attacks”? Or do the “attacks” re-activate the virus because poor perfusion through damaged endothelium leads to oxygen deficiency? (I don’t favor trying to “kill” a dormant EBV Herpes virus with anti-viral drugs. The original illness may have already damaged the veins and the drugs will only weaken the immune system further. At the most I may try the anti-herpes herbal remedy Larrea tridentata, mainly to prevent a shingles attack. Also, I would never try the HSCT stem cell therapy – recently in the news - in which the immune system is destroyed with high dose chemotherapy after which stem cells are administered to “reboot” the immune system. Better strengthen one’s overall health to keep a dormant virus at bay rather than damage the immune system – or risk death - with drugs. That strikes me as an unnecessarily drastic way to detoxify.)
In the meantime, anyone who seriously seeks to heal MS can’t ignore nutrition. Proper diet serves 4 purposes: 1) to prevent body stress - on the vascular system i.e. the blood reflux and/or on the cerebro-spinal fluid 2) to heal and reinforce the endothelium of the vascular system at the cellular level 3) to nourish the brain cells (white matter, myelin sheath, axons, grey matter) especially important if there has been some brain damage and 4) to re-inforce the immune system in order to de-activate a latent virus or bacteria (probably Epstein-Barr virus – cause of Mononucleosis - for me). One note: before diet change and supplements could work for me I had to go through a profound detoxification and I needed the help of a naturopath/kinesiologist to do it.
One final note: Consider that you may have Lyme disease or a serious Vitamin B12 deficiency which can mimic MS symptoms. See Resources section for blood test suggestions.
Even though Dr. Zamboni's insight has come a bit late for me, it has given me a new lease on life. I used to live in constant fear of a debilitating relapse. Now I know what to do to head off a breakdown. Having embarked once again on my diet I feel better and hopeful of improvement in the future. I know that anything which improves blood/brain fluid circulation (swimming, acupuncture, acupressure, massage, kinesiology, osteopathic, chiropractic, any energy therapy – AND fifteen minutes of Sun a day) will make me feel better and prevent a relapse. As I’ve gotten control over the blood reflux into the brain, I’ve come to see the importance of keeping my spine strong and stabilized. Optimal nutrition and supplements and oxygen can keep my blood vessels as well as the brain’s grey matter healthy. And I need to be ever vigilant in avoiding illnesses which might trigger the latent EBV virus.
I hope other Multiple Sclerosis patients will reflect on their own history and that my experience will be of use in their Healing.
See Resources/Better Blogs for references
July 28, 2016
(Version 1 - February 15, 2012. Version 2 – June 8, 2013. Version 3 August 1, 2014. Version - 4 July 1, 2015 Version 5 CCSVI MS Udated - 2016 See earlier versions under pages more...)
Anna Macy is an American writer living in Paris.
She can be reached at firstname.lastname@example.org
*Cerebral Circulation Time is Prolonged and Not Correlated with EDSS in Multiple Sclerosis Patients: A Study Using Digital Subtracted Angiography
Tags: Multiple Sclerosis, MS Diagnosis, Functional Disorder, Dr. McGuckin, Dr. George Ebers, CCSVI, Chiropractors, Osteopaths, Dr. Michael Flanagan