:
After careful analysis of my own experience and relevant research, I have come to think MS progression is characterized by increasing obstruction of cerebro-spinal fluid and/or direct pressure on the spinal cord so that venoplasty treatment for CCSVI will become less and less effective in bringing relief to handicap. (See MS Positive Feedback Loop under Cure or Control, and RRMS Progresses to SPMS blog Jan 21, 2015. My quote follows.)
« Eventually the body rigidity/muscle spasms deform and damage the spine. As muscles weaken and atrophy the entire body structure is compromised leading to obstructed cerebrospinal circulation and direct pressure on the spinal cord. At this point it is no longer the blood reflux inflammation which “wound” the nerves so much as lesions and cerebrospinal fluid obstructions which impact the spine. We now have SPMS and increasing issues with mobility. Ideally MSers should turn to functional healers – Osteopaths and Chiropractors - who can manipulate the head/cervicals/full length of the spine to relieve pressure on the spinal cord and free the cerebro-spinal fluid. Physical Therapists and Massage Therapists can provide fluidity and movement so vital to overcoming the natural tendency to rigidity ».
When I first read about Dr Zamboni(s « liberation therapy » summer 2010, I was still living the RRMS stage of MS. I could get the blood flowing out of my head towards the heart to relieve an impending attack through a simple massage or a TENS acupressure treatment. My condition was stable, I assumed it would remain so as long as I faithfully adhered to MY SEVEN STEPS TO MULTIPLE SCLEROSIS HEALTH https://www.mscureenigmas.net
Unfortunately, I no longer enjoy that immediate relief in releasing CNS fluid flow. I still use the TENS but any relief it may give is subtle at best. And between Dec 2019 and May 2020 my condition seriously declined. My MS has progressed.
What happened ? The most serious consequence came with a fall which broke my right arm in October 2019. After I broke the right shoulder years before which was improperly treated, my right arm functioned poorly, and this last break meant it barely worked at all, the muscles pulled it up into tense rigidity. My Osteopath explained that the muscles in my pelvis were so tense that they pulled up the right leg which became shorter than the left. In consequence I can’t stand on both legs at once unless they are bent, a very unpleasant condition.
This might not have happened had I been treated over the 5 months between Dec and May. I wasn’t treated during my stay in Spain and upon our return March 20, 2020 the Covid confinement prevented Osteopathic treatment. When I resumed physical therapy mid May, it was very clear I had lost ground.
Recently I found this Japanese research on ThisisMS.com which could well explain what has happened. https://www.thisisms.com
« Endothelial dysfunction Post by Petr75 » Mon Jul 19, 2021 5:40 am
2021 Jul 2
Department of Neurology and Geriatric Medicine, Ehime University Graduate School of Medicine, Toon City, Ehime, Japan !
Vascular endothelial dysfunction associated with severity in multiple sclerosis
https://pubmed.ncbi.nlm.nih.gov/34274738/
Abstract
Background: Impairment of cerebrovascular reactivity (CVR) has been reported in patients with multiple sclerosis (MS). Chronic inflammation and endothelial dysfunction are possible mechanisms underlying this hemodynamic impairment. This study aimed to evaluate CVR and endothelial function in patients with MS and explore their relationships with disease progression using functional sonographic procedures.
Methods: Patients with MS and age-/sex-matched healthy controls were assessed for endothelial function, determined by flow-mediated dilation (FMD), and CVR, measured using the breath-holding index (BHI).
Results: Twenty-seven patients with MS and 24 healthy controls were enrolled. FMD was significantly lower in MS subjects than in control subjects (6.0 ± 0.6 vs. 8.6 ± 0.7, p = 0.006); furthermore, BHI was similarly lower in MS than in controls, but insignificant. Remarkably, FMD was significantly lower in secondary progressive MS subjects than in relapse-remitting MS subjects (3.7 ± 1.3 vs. 6.7 ± 0.7, p = 0.045). In addition, FMD was inversely correlated with the disability score as per the expanded disability status scale (R2 = 0.170, p = 0.033) and modified Rankin scale (R2 = 0.187, p = 0.027).
Conclusion: In patients with MS, endothelial dysfunction was more noticeable than CVR impairment, correlating with the severity and progression of MS. »
When I asked Christina Willman (who writes under the pseudonym Irontina) what this could mean, she responded as follows :
« About the article you shared, VERY interesting!
From my understanding:
Flow-mediated dilation is seen when venous flow is slow and/or the pressure becomes elevation and dilates the vessels. This concept is what Zamboni's and others would say might be causing MS lesions because when the vessels dilates, particles can pass through which normally wouldn't/shouldn't causing an inflammatory response and myelin breakdown from the response.
So, MSers have lower FMD scores because they have slower flow through a restricted vessel causing the dilation and such.
Then, the FMD and disability scores are inverted because the lower the FMD score (slower the blood flow--> causing increased pressure--> causing dilation of the vessel --> INCREASES the disability score (lower flow = more disability)... did I say that in a way that makes sense??
This is where I'm getting tripped up...
Is slower flow and more DEoxygenated blood in the brain effecting the symptoms/disabilities?
Or does the decreased myelin causing the disabilities?
If I don't have lesions, how is my function worse?
HOWEVER, if I have SLOWER flow of DEoxygenated blood OUT of my brain therefore increasing the amount of that blood in my brain, maybe that is causing the problem??
Why did improvement of the blood flow in the IJVs have such a significantly positive outcome? Now it's been 2.5 years I've had WORSE flow in the IJVs, my symptoms are worse, blood thinner helps but I have less lesions....?
What happens to astronauts, pilots, scuba divers when they have decreased oxygen to the brain...
THE SAME THING (SYMPTOMS) MANY MS PATIENTS HAVE ALL THE TIME! Headache, brain fog, visual disturbance, coordination/balance problems...
Maybe progressive MSer have MORE vascular lesions/strictures therefore having significantly more blood flow issues which cause more symptoms and quicker decline...
Maybe secondary progressive is when the body had reached a tipping point of not being able to accommodate the poor blood flow anymore.. »
Excellent discussion, Christina.
I would say her last line describes my situation over the past 18 months. It was my hope that by freeing the pelvic muscles my shortened right leg could be lengthened and I could recover movement in walking. Even though weekly osteopathic adjustments over the past three months have helped me, I haven’t recovered my former strength nor equal balanced leg length. I am very weak and stumble more than walk. (Lately I’ve wondered if I have a low grade infection which is weakening me.)
I intend to continue this discussion in future posts. As we will see in future articles on MS Progression, it is almost impossible for MS researcherss to give up on the drug solution. If the primary probem resides in the venous structure and/or skeletal, how can any drug rectify it ?
Some positive news. I had stopped dreaming which for me implied poor brain function perhaps as a consequence of poor fluid circulation.
Recently I dreamed of a spring garden, rich dark soil on which were planted widely spaced primroses. Does this not herald a wonderful renewal of the life force ? I can only see here the success of unblocking my skeletal structure to release the « fluid » circulation.
Tags : Vascular endothelial dysfunction, (CVR) cerebrovascular reactivity, (FMD) flow mediated dilation, SPMS, RRMS
.
After careful analysis of my own experience and relevant research, I have come to think MS progression is characterized by increasing obstruction of cerebro-spinal fluid and/or direct pressure on the spinal cord so that venoplasty treatment for CCSVI will become less and less effective in bringing relief to handicap. (See MS Positive Feedback Loop under Cure or Control, and RRMS Progresses to SPMS blog Jan 21, 2015. My quote follows.)
« Eventually the body rigidity/muscle spasms deform and damage the spine. As muscles weaken and atrophy the entire body structure is compromised leading to obstructed cerebrospinal circulation and direct pressure on the spinal cord. At this point it is no longer the blood reflux inflammation which “wound” the nerves so much as lesions and cerebrospinal fluid obstructions which impact the spine. We now have SPMS and increasing issues with mobility. Ideally MSers should turn to functional healers – Osteopaths and Chiropractors - who can manipulate the head/cervicals/full length of the spine to relieve pressure on the spinal cord and free the cerebro-spinal fluid. Physical Therapists and Massage Therapists can provide fluidity and movement so vital to overcoming the natural tendency to rigidity ».
When I first read about Dr Zamboni(s « liberation therapy » summer 2010, I was still living the RRMS stage of MS. I could get the blood flowing out of my head towards the heart to relieve an impending attack through a simple massage or a TENS acupressure treatment. My condition was stable, I assumed it would remain so as long as I faithfully adhered to MY SEVEN STEPS TO MULTIPLE SCLEROSIS HEALTH https://www.mscureenigmas.net
Unfortunately, I no longer enjoy that immediate relief in releasing CNS fluid flow. I still use the TENS but any relief it may give is subtle at best. And between Dec 2019 and May 2020 my condition seriously declined. My MS has progressed.
What happened ? The most serious consequence came with a fall which broke my right arm in October 2019. After I broke the right shoulder years before which was improperly treated, my right arm functioned poorly, and this last break meant it barely worked at all, the muscles pulled it up into tense rigidity. My Osteopath explained that the muscles in my pelvis were so tense that they pulled up the right leg which became shorter than the left. In consequence I can’t stand on both legs at once unless they are bent, a very unpleasant condition.
This might not have happened had I been treated over the 5 months between Dec and May. I wasn’t treated during my stay in Spain and upon our return March 20, 2020 the Covid confinement prevented Osteopathic treatment. When I resumed physical therapy mid May, it was very clear I had lost ground.
Recently I found this Japanese research on ThisisMS.com which could well explain what has happened. https://www.thisisms.com
« Endothelial dysfunction Post by Petr75 » Mon Jul 19, 2021 5:40 am
2021 Jul 2
Department of Neurology and Geriatric Medicine, Ehime University Graduate School of Medicine, Toon City, Ehime, Japan !
Vascular endothelial dysfunction associated with severity in multiple sclerosis
https://pubmed.ncbi.nlm.nih.gov/34274738/
Abstract
Background: Impairment of cerebrovascular reactivity (CVR) has been reported in patients with multiple sclerosis (MS). Chronic inflammation and endothelial dysfunction are possible mechanisms underlying this hemodynamic impairment. This study aimed to evaluate CVR and endothelial function in patients with MS and explore their relationships with disease progression using functional sonographic procedures.
Methods: Patients with MS and age-/sex-matched healthy controls were assessed for endothelial function, determined by flow-mediated dilation (FMD), and CVR, measured using the breath-holding index (BHI).
Results: Twenty-seven patients with MS and 24 healthy controls were enrolled. FMD was significantly lower in MS subjects than in control subjects (6.0 ± 0.6 vs. 8.6 ± 0.7, p = 0.006); furthermore, BHI was similarly lower in MS than in controls, but insignificant. Remarkably, FMD was significantly lower in secondary progressive MS subjects than in relapse-remitting MS subjects (3.7 ± 1.3 vs. 6.7 ± 0.7, p = 0.045). In addition, FMD was inversely correlated with the disability score as per the expanded disability status scale (R2 = 0.170, p = 0.033) and modified Rankin scale (R2 = 0.187, p = 0.027).
Conclusion: In patients with MS, endothelial dysfunction was more noticeable than CVR impairment, correlating with the severity and progression of MS. »
When I asked Christina Willman (who writes under the pseudonym Irontina) what this could mean, she responded as follows :
« About the article you shared, VERY interesting!
From my understanding:
Flow-mediated dilation is seen when venous flow is slow and/or the pressure becomes elevation and dilates the vessels. This concept is what Zamboni's and others would say might be causing MS lesions because when the vessels dilates, particles can pass through which normally wouldn't/shouldn't causing an inflammatory response and myelin breakdown from the response.
So, MSers have lower FMD scores because they have slower flow through a restricted vessel causing the dilation and such.
Then, the FMD and disability scores are inverted because the lower the FMD score (slower the blood flow--> causing increased pressure--> causing dilation of the vessel --> INCREASES the disability score (lower flow = more disability)... did I say that in a way that makes sense??
This is where I'm getting tripped up...
Is slower flow and more DEoxygenated blood in the brain effecting the symptoms/disabilities?
Or does the decreased myelin causing the disabilities?
If I don't have lesions, how is my function worse?
HOWEVER, if I have SLOWER flow of DEoxygenated blood OUT of my brain therefore increasing the amount of that blood in my brain, maybe that is causing the problem??
Why did improvement of the blood flow in the IJVs have such a significantly positive outcome? Now it's been 2.5 years I've had WORSE flow in the IJVs, my symptoms are worse, blood thinner helps but I have less lesions....?
What happens to astronauts, pilots, scuba divers when they have decreased oxygen to the brain...
THE SAME THING (SYMPTOMS) MANY MS PATIENTS HAVE ALL THE TIME! Headache, brain fog, visual disturbance, coordination/balance problems...
Maybe progressive MSer have MORE vascular lesions/strictures therefore having significantly more blood flow issues which cause more symptoms and quicker decline...
Maybe secondary progressive is when the body had reached a tipping point of not being able to accommodate the poor blood flow anymore.. »
Excellent discussion, Christina.
I would say her last line describes my situation over the past 18 months. It was my hope that by freeing the pelvic muscles my shortened right leg could be lengthened and I could recover movement in walking. Even though weekly osteopathic adjustments over the past three months have helped me, I haven’t recovered my former strength nor equal balanced leg length. I am very weak and stumble more than walk. (Lately I’ve wondered if I have a low grade infection which is weakening me.)
I intend to continue this discussion in future posts. As we will see in future articles on MS Progression, it is almost impossible for MS researcherss to give up on the drug solution. If the primary probem resides in the venous structure and/or skeletal, how can any drug rectify it ?
Some positive news. I had stopped dreaming which for me implied poor brain function perhaps as a consequence of poor fluid circulation.
Recently I dreamed of a spring garden, rich dark soil on which were planted widely spaced primroses. Does this not herald a wonderful renewal of the life force ? I can only see here the success of unblocking my skeletal structure to release the « fluid » circulation.
Tags : Vascular endothelial dysfunction, (CVR) cerebrovascular reactivity, (FMD) flow mediated dilation, SPMS, RRMS
.
RSS Feed